23^rd International Conference on New Horizons in Cardiology & Cardiologists Education December 10-11, 2020 Osaka, Japan

Biography:

Veena Dhawan has completed her PhD from PGIMER and did Post-doctoral Research at Minneapolis USA and Post-graduate Institute of Medical Education and Research, Chandigarh, India. At present, she is working as a Professor in the Department of Experimental Medicine and Biotechnology at PGIMER a National Institute of repute. She has published around 90 papers in reputed journals and written around seven book chapters.

Abstract:

Atherosclerosis is the underlying cause of coronary artery disease (CAD) and a disease of multifactorial etiology. Recent investigations in atherosclerosis have been focused on inflammation and endoplasmic reticulum (ER) stress, providing new insights into the mechanism of the disease. Keeping in view the multifactorial aspects of this disease, novel strategies are urgently needed not only for identification of novel biomarkers, but also to search for remedies for prevention and treatment of this disease. C-reactive protein (CRP) is reported to be a biomarker of inflammation in CAD and is shown to actively contribute to the disease pathology. Our data from in vitro studies provided substantial evidence that MMP-TIMP and RAGE-EN-RAGE interactions significantly contribute to the pathophysiology of coronary artery disease. CRP was found to play a potential role in the induction, amplification, and prolongation of inflammatory response in atherosclerosis via modulating these genes and atorvastatin showed the potential to curb the deleterious effects of CRP. However, it is evident that besides use of several drugs like statins, inflammation persists in CAD patients. Therefore, we conducted studies with Terminalia arjuna (TA), a medicinal plant with a wide variety of applications in traditional medicine and referred to as a cardiotonic in Ayurvedic system of medicine. Evidence in literature demonstrates that TA like atorvastatin possesses pleotropic properties. Studies carried out in our laboratory have clearly demonstrated its anti-inflammatory and antithrombotic properties both in vitro as well as in vivo and in experimental animals. Expression of inflammatory genes eg: was found to be significantly reduced in vitro in a dose and time-dependent manner by Terminalia arjuna. Using a Systems Biology approach, observations of the in vitro study were further validated in a randomized, placebo-controlled, double-blind clinical trial in subjects with stable CAD who received either placebo or T. arjuna (500 mg twice a day; Himalaya) and were followed up to six months. TA was shown to attenuate inflammation and played a pivotal role in modulation of both cellular and humoral immunity. Chronic ER stress is implicated in the pathophysiology of atherosclerosis and is found to be associated with apoptosis. Research work in our lab demonstrated that TA specifically targeted early foam cell apoptosis via activation of unfolded protein response pathway. The data from our studies suggests use of a multipronged approach using novel therapies in terms of combination/adjuvant therapy in clinical studies utilizing indigenous resources of medicinal plants to prevent/treat complex disorders such as CAD.

Biography:

Cindy Rodrigues Cleto is a sixth year Medical Student at the University of Liverpool, UK. She has completed her MReS in Cardiovascular Science at the University of Newcastle where she carried out this research.

Abstract:

Introduction: Primary cilia on endocardial cells could prove to be a cause of congenital heart defects. Endocardial cells mainly contribute to the outflow tract (OFT) and atrioventricular (AV) endocardial cushion; later developing into the four heart valves. Knocking out IFT88 creates abnormal primary cilia and in turn causes cardiac malformations.

Aims: The aims of this study were to establish the spatiotemporal expression of primary cilia on endocardial derived cells; and by using an IFT88 mouse model, to discover if defecting to the primary cilia in endocardial derived cells causes an abnormal cardiac phenotype?

Methods: For the spatiotemporal expression of primary cilia, Tie2Cre positive mouse embryos of age’s e10.5-e12.5 were stained with anti-green fluorescent protein and acetylated tubulin to show the endothelial cells and primary cilia respectively. For the IFT88 mouse model, three mutants were collects at e15.5; two were hematoxylin and eosin stained to look at histology and one was stained with acetylated tubulin to show any defect in the primary cilia.

Results: The spatiotemporal expression of primary cilia mainly highlighted that there is an abundance of cilia in the OFT and AV endocardial cushions at e10.5 and e11.5 but this significantly drops by e12.5. The IFT88 mouse model showed that knocking out IFT88 significantly decreases the number of primary cilia in mutants, causing cardiac malformations including atrio-ventricular septal defects and dysplastic mitral and tricuspid valves.

Conclusion: Primary cilia are present in the endocardial derived cells at earlier time points. Knocking out IFT88 does produce defective cilia that lead to cardiac malformations.

Biography:

Flavio Burgarella is a Cardiologist and Physiatrist, Head of the Cardiac Rehabilitation Center of San Pellegrino Terme, in the province of Bergamo, Italy. He is registered with the National Associations of Journalists. He is the Founder and Executive Director of Heart Friends Around The Word, (www.hfatw.org) international association, affiliated with the World Heart Federation, whose aim is to promote the prevention and rehabilitation of cardiovascular diseases in developing nations. He is the Founder and Chairman of Burgarella Quantum Healing (BQH) (www.quantummind.eu ) with the aim to promote the helping relationship between Science and Consciousness. He is an Honorary Member of the Russian Federation of Cardiology and the Cuban Atherosclerosis Society. He got for his activity the Sodalem Honoris Causa by the Society of MD of the Slovak Republic. He has published several books on health education and five books of poetry. He organized several campaigns to promote health through physical activity, including three jogging tour of Italy in relay. He is enrolled at the Science and Consciousness Group of the Faculty of Psychology of the University of Padua and collaborates with Egocreanet at the Incubator of the University of Florence (Italy).

Abstract:

Flavio Burgarella is a Cardiologist and Physiatrist, Head of the Cardiac Rehabilitation Center of San Pellegrino Terme, in the province of Bergamo, Italy. He is registered with the National Associations of Journalists. He is the Founder and Executive Director of Heart Friends Around The Word, (www.hfatw.org) international association, affiliated with the World Heart Federation, whose aim is to promote the prevention and rehabilitation of cardiovascular diseases in developing nations. He is the Founder and Chairman of Burgarella Quantum Healing (BQH) (www.quantummind.eu ) with the aim to promote the helping relationship between Science and Consciousness. He is an Honorary Member of the Russian Federation of Cardiology and the Cuban Atherosclerosis Society. He got for his activity the Sodalem Honoris Causa by the Society of MD of the Slovak Republic. He has published several books on health education and five books of poetry. He organized several campaigns to promote health through physical activity, including three jogging tour of Italy in relay. He is enrolled at the Science and Consciousness Group of the Faculty of Psychology of the University of Padua and collaborates with Egocreanet at the Incubator of the University of Florence (Italy).

Biography:

Yin Hua Zhang is a Cardiovascular Physiologist evaluating cardiac metabolism in health and diseased hearts. She has been working on nitric oxide and redox-regulation of myocardial contractility and cellular mechanisms. She is now focusing on obesity and hypertension and cardiovascular remodeling.

Abstract:

Transglutaminase 2 (TG2) is a calcium-dependent enzyme and in the cardiovascularsystem, TG2 has been reported to be involved in the development of cardiac hypertrophy, vessel remodeling, and age related vascular stiffness. Interestingly, TG2 is implicated in the regulation of muscle metabolism via modification of respiratory complexes and the ADP/ATP transporter in the mitochondria of myocardium. However, the role of TG2 in the heart during conditions of pressure overload in relation to fatty acid(FA) oxidation has not been investigated. Hence, we investigated the involvement of TG2 in cardiomyocytes contraction under FA supplementation. Using TG2 inhibitor and TG2-deficient mice, we demonstrated that FA-supplementation activated TG2 and increased ATP level and contractility of cardiac myocyte from normal heart. By contrast, in cardiac myocytes from angiotensin-II treated rats and mice, the effects of FA-supplementation on TG2 activity, ATP level and myocyte contraction were abolished. Furthermore, TG2 was inhibited by S-nitrosylation and its level increased in hypertensive myocytes. Treatment with inhibitor for neuronal nitric oxide synthase (nNOS) restored FA-induced increase of TG2 activity and myocyte contraction. Moreover, intracellular Ca2+ levels were increased by FA-supplementation in both normal and hypertensive myocytes, showing that S-nitrosylation of TG2 but not alteration of intracellular Ca2+ levels are responsible for contractile dysfunction. These results indicate that TG2 plays a critical role in the regulation of myocyte contractility by promoting FA metabolism and provide a novel target for preventing contractile dysfunction in heart with high work-load.

Biography:

Ahdi Amer is a Professor of Pediatrics at Wayne State University School of Medicine, Detroit, Michigan. He has expertise in the field of General Academic Pediatrics and Pediatric Infectious Diseases. His main areas of interest are vaccine development, vaccine safety, and various pediatric infectious and dermatological disorders. He has conducted clinical research supported by the WHO, Merck and Pfizer on vaccines and other infectious and dermatological topics. He has authored and co-authored >40 articles published in peer-reviewed journals. He has presented in several national and international settings on vaccine-related topics.

Abstract:

Background & Objective: Non-nutritive sucking (NNS) using a finger or pacifier is a natural reflex for infants. In gratifying this innate need, NNS can be soothing and may facilitate a smooth transition to sleep. We hypothesized that infants with their innate desire for gratification through NNS may overfeed if the bottle or breast is constantly offered instead of a pacifier. Our primary objective was to determine whether the use of pacifier in early infancy is associated with lower incidence of obesity at 9-15 month of age.

Methods: Parents of 399 infants 9 to 15 months old visiting the General Academic Pediatric Clinic were interviewed. They were asked whether a pacifier was used consistently ≥9 months and the reason for its use. BMIs at birth, 6 months and on the day of interview were calculated.

Results: Of the 399 recruited infants, 204 (51%) used a pacifier consistently for ≥9 months and 195 (49%) were non-user. More infants in the pacifier non-user group were significantly either overweight, 40 (21%) with BMI ≥85% or obese, 32 (16%) with BMI ≥95% than in the pacifier user group: 22 (11%) and 22 (11%) respectively (P.003). Formula fed infants accounted for the increased number of overweight and obese infants in the non-user group.

Conclusions: The use of a pacifier in infancy was associated with a lower incidence of obesity at 9-15 month of age. Given the current prevalence of childhood obesity, we believe that offering a pacifier between feeds can provide a protective effect against infantile obesity.

Biography:

Abel Gidey is one of the youngest energetic and affable pediatricians working in Ayder specialized Comprehensive Hospital, Ethiopia. He has finished his Medical Doctor in 2014 and is an Assistant Professor of Pediatrics since October 2018. He was one of the speaker at the World Pediatric Conference December 2018 which was held in Abu Dhabi, UAE.

Abstract:

Systemic lupus erythematosus (SLE) is a chronic inflammatory disease of unknown cause that can affect the multiple organs of the body. Cardiac involvement among children with SLE ranges in various studies from 12 to 54 percent. The manifestations are varied in nature and severity. Valvular lesion is the most encountered form of heart disease in systemic lupus erythematosus (SLE). The mitral valve being the commonest site. We report a case of 16 years old male adolescent who was referred from district hospital in Tigray region. He was newly diagnosed Systemic lupus erythematosus with rapid progression of valvular insufficiency and congestive heart failure. This is one of the rare case reports with diagnostic and therapeutic challenge.

Biography:

Lidia Sileshi Tefera has completed her graduation from Hawassa University school of Medicine with a Medical degree and completed her Residency in Pediatrics and Child health from Addis Ababa University School of Medicine. She is the Head of Department of Pediatrics and Child health in Adare General Hospital and Affiliated Staff of Hawassa University College of Medicine and Health Sciences.

Abstract:

While the health-related quality of life (HRQOL) of children with congenital heart defects is primarily affected, caring for a child with birth defect has an impact on the family’s quality of life as well. Understanding the level of quality of life of the parents, which is likely to vary in different cultural settings, beliefs and parental educational status may help to implement educational programs and other interventional measures that may improve the HRQOL of parents of such children. This cross-sectional comparative study reports the health-related quality of life of mothers of children with congenital heart diseases in a sub-Saharan setting. Mean age of the mothers in the study group was 32.2±7.1 years where as that of the control group was 30.5±6.5 years (p=.054). One hundred-four children had congenital cardiac lesions classified as mild to moderate while 31 patients had severe lesions. On average, mothers in the study group showed poor performance on the Short Form-36 (SF-36) survey with statistically significant differences on all sub-scales including general health perception, physical functioning, role physical, role emotional, social functioning, bodily pain, vitality and mental health. Severity of the congenital heart defect was not associated with statistically significant difference in the health-related quality of life of the mothers. Mothers of children with congenital heart disease in our study have significantly lower quality of life in all domains of SF-36 compared to the control group. Planning and devising a strategy to support these mothers may need to be part of management and clinical care of children with congenital heart diseases.

Biography:

Angela Harrinanan is a nursing professor at Centennial College with extensive pain management experience in acute pain service. She also works at Centennial Health Simulation center as a simulation support for faculty with limited simulation experience. Angela holds a Master in Nursing from University of Toronto, specializing in Nurse Practitioner.

Abstract:

Introduction: Pain management has been identified as one critical element in nursing practice and students are required to assess and manage pain appropriately. Many studies support the effectiveness of simulation as a teaching methodology; however there is a gap in measuring students’ learning outcomes in pain simulation. The purpose of this study is to assess students’ knowledge of pain assessment and management. Furthermore this research study is to explore students’ perspectives in pain simulation.

Research Question/Hypothesis: Will the pain simulation experience improve students’ knowledge of pain (a) assessment and (b) management? (c) What is the students’ perspective/experience when participating with the pain simulation?

Methods: A mixed methods approach was utilized to gain an understanding of student’s learning of pain assessment and management in simulation. A convenience sample of 159 year two BSc Nursing students were recruited for Adapted Pain Knowledge and Attitude Pre- and Post-Simulation Surveys during their scheduled simulation experience in winter 2018 semester. Additionally, 10 students participated in focus group sessions to explore nursing students’ experience in pain simulation.

Results: Descriptive and qualitative data were analyzed with five themes emerging: Developing appropriate pain assessment skills, administrating pain medication with clinical reasoning, enlightening pain management from patient’s perspective, developing clinical decision making and providing new perspective of pain management. Themes were derived from qualitative focus group findings and aligned with the pre- and post-pain knowledge and attitude survey (PPKAS) quantitative results (McCaffery and Ferrel, 2012). Key learning points that student have gained from pain simulation experience are: Communicating effectively with patient, do not underestimate patient’s pain, acquiring “solid” pain medication knowledge to provide safe patient care, “Practice makes perfect” and tailoring pain medication based on patient’s conditions.

Conclusion: The PPKAS surveys and focus group discussions reveal student’s learning perspectives and suggestions for future pain simulation to; supporting student learning in pain simulation; fostering student centered learning simulation environment and; providing faculty support in pain simulation.

Biography:

Stavros Theologou works as a Registered ITU Nurse in Cardiac Surgery ICU of ‘Evangelism’s’ General Hospital of Athens. He completed a Post-graduate course in ‘Intensive Therapy Units and Emergency Nursing’ in Medical School of National and Kapodistrean University of Athens and a Post-graduate course in Health and Social Welfare Services in School of Business Administration of University of West Attica and currently is a PhD candidate in Medical School of Athens. He has also contributed in publications in several reputed scientific health journals.

1: Registered ITU Nurse, ΜSc, PhD (c) Cardiac Surgery ICU, ‘Evangelismos’ General Hospital of Athens, Greece.  

2: Research Fellow,  MSc,  PhD (c),  Department of Nursing, Center for Health Services Management and Evaluation, National and Kapodistrian University of Athens, Athens, Greece.

3: Assistant Professor, ΜSc, PhD,  Department of Economics of the University of Piraeus, Director at the Laboratory of the Health Economics and Management of University of Piraeus

Abstract:

Introduction: The hospitalization of post cardiac surgery ICU patients constitutes a complex mixture of procedures affected by a variety of clinical, administrational and technical aspects of care. The respective cost may drastically increase due to these patients’ increased clinical needs, including also the clinical state of delirium which is a quite common complication following this type of operation.

Methods: Τhe study included 179 consecutive patients who underwent open heart operation with cardiopulmonary bypass. The Confusion Assessment Method (CAM-ICU) was used for delirium diagnosis. Hospitalization outcomes were recorded by measuring certain intra - and post - operative procedure time intervals, along with the ICU and in-hospital length of stay as well.

Results:

A total of 179 patients post cardiac surgery were investigated, 129 of them were male and the rest 50 were female. The delirium complication was recorded in 20 out of 179 patients of the study (11.2%)

Bivariate analysis revealed that prolonged intraoperative time in cardiopulmonary bypass (p<0,001), prolonged sedation time (p=0,005) and prolonged length of stay with endotracheal tube (p<0,001) were significantly correlated with increased total health care cost.

Multivariate analysis showed that the level of complexity of the surgical operation (p<0,001), delirium complications (p<0,001) and the prolonged in-hospital length of stay (p<0,001), formulated altogether a group of factors for total health care cost increase.

Conclusions: A variety of factors seem to increase post cardiac surgery ICU patients’ total hospitalization cost and jeopardize quality of care and health outcomes.

Biography:

Dr. John Oda is recognized as one of the top entrepreneurs worldwide. He was featured in “Meeting the Giants,” working with renowned speakers such as Anthony Robbins, Stephen Covey, Jack Canfield, and Les Brown. He is also regarded as a business expert on the Evan Carmichael website. His writings appear alongside other greats like: Warren Buffet, Bill Gates, Timothy Ferriss, and Donald Trump.

Dr. Oda has been featured as a guest on “Oprah and Friends,” interview by Maya Angelou.  ABC television, and has served as a radio host on PBS' online radio with his own personal development show.

Abstract:

Dr. John Oda is recognized as one of the top entrepreneurs worldwide. He was featured in “Meeting the Giants,” working with renowned speakers such as Anthony Robbins, Stephen Covey, Jack Canfield, and Les Brown. He is also regarded as a business expert on the Evan Carmichael website. His writings appear alongside other greats like: Warren Buffet, Bill Gates, Timothy Ferriss, and Donald Trump.

Dr. Oda has been featured as a guest on “Oprah and Friends,” interview by Maya Angelou.  ABC television, and has served as a radio host on PBS' online radio with his own personal development show.

In 1995, Dr. Oda met and teamed up with bestselling author and Peak Performance Expert, Joseph McClendon III, a head trainer for the Anthony Robbins organization. His educational background includes a Doctorate in Philosophy (emphasis in Psychology) and certifications in Neuro-Linguistic Programming Master Trainer (NLP). Dr. Oda has also specialized in phobia and emotional challenges during twenty years of practicing.

Dr. Oda is frequently called upon to provide Corporate Training, Workshops, and Seminars for many companies worldwide because of the special skills and experiences Dr. Oda naturally provides. He is Master Coach and has trained three of the Top Ten Coaches at Business Breakthroughs International, LLC, an Anthony Robbins, Chet Holmes Company, a Master Trainer with Scott Hallman.  Dr. Oda is an expert in Time Management, Sales Training, and Leadership and also helps business professionals in overcoming the behaviors and obstacles which impede their sales results and affect their bottom line.

Dr. John Oda's work provides new insight and solutions to current business issues, working as an executive business coach for 15 years and helping to increase a company's sales from 25% - 3,000% annually. His strategies and tools for change can prove value for any business size.

Dr. Oda has a remarkable ability to go straight to the core of a person's challenges and effect rapid change, making him a valuable commodity as a turnaround specialist in the business and private arenas. He does this with his unique brand of leadership, presentation style, humor and passion for living. His ability to inspire others to take action and to achieve greater results, are principles of living that he upholds.  Dr. Oda is an author of Connecting with Your Teen provides workshops for teens and parents around the world.

DR. JOHN ODA CONSULTING CLIENTS INCLUDE:

• Hideki Electronics, Inc.
• State Farm
• Bethlehem Steel Corporation
• Keller Williams Realty
• H2O Waste Management
• Medical Offices
• Emergency and Urgent Care
• Century 21
• Blue Chip Casino
• Portland Community College
• Primerica
• MLM
• Power House Gym
• Kelley Services
• The Olympia
• Restaurants
• Nielsen Dealership ( Subaru, Kia, Mitsubishi, and Hyundai)
• Chiropractor Offices
• HBW Financial Services
• Coffey Labs
• Orion Solar Racking
• Lighting Companies
• Software Company
• Sports Industry
• Transportation
• Entertainment
• SW Foods
• Construction ( Residential and Commercial)
• Legal
• Manufacturing Companies
• Securities and Commodity Exchange
• Social Media Companies
• Advertising Agency
• SEO/Website Company
• Mobile application company
• BMW Dealership
• Thompson Auto Group ( Toyota, Nissan, Suzuki)

HERE IS WHAT THE EXPERT IS SAYING:

“With a style all his own and vigor that inspires others to take action, John is a true crusader for assisting others in making a positive change in their lives. The lives of those they love. I’m proud to call him a friend. My wish for you is that you too will come to work with him, and know him as well. Dr. Oda will add ten times the value. I guarantee it!”

- Joseph McClendon III, co-author with Anthony Robbins on two bestselling books and a UCLA instructor

HERE IS WHAT CLIENTS ARE SAYING ABOUT DR. JOHN ODA:

“John Oda has been my business coach for the past eight months. He has taught me strategies to take my business to the next level.  Johns' time management structures have helped me increase my business dramatically without increasing my hours dramatically.  What sets John apart from other coaches is his ability to help me grow as a person as well as a business owner.   He teaches that a healthy mind, body and personal life are extremely important foundations for a healthy growing business.   The hidden treasure in Johns coaching is his ability to shift you to a mindset of success.  A coaching session with John Oda is tantamount to a coaching session with Anthony Robbins, Napoleon Hill and Joseph McClendon III all rolled into one. The guy knows his stuff.

Oh by the way, I employ 10 great people, in the last eight months my business has doubled and my NET PROFIT is up 120% and we're just getting warmed up. Thanks mate.”

-Rob Heidemanns, Canberra, Australia

“We wanted to say, "Thank you!"  During the time you have been coaching us, NeuroQuest has achieved so much more than what we had been doing on our own.  As small business owners and having worked for a fortune 500 companies for many years, we were hesitant to work with a coach.  Not only did we think we had all the answers, but as with any upstart, we were short on cash.  We're so glad you were persistent and patient with us.  Your coaching has enabled us to gain clarity in our business and personal life which has translated into massive progress and success.  We know this is only the beginning!  We have found that through your direction, focus and the challenge to think outside the box we have secured more contracts, increased our orders and collections, as well as help us overcome a partnership issue we had been floundering in. The confidence we have in you and your coaching style along with the excitement you help generate will take us to the next level of success and company security.  Anyone serious with either their company success or personal success needs you as their coach.  Thanks Coach, the results in our business have already paid for the coaching!” In the last two years my business has increase over 900%.

-Christy Norton, President and Leslie Chase

“Dear John Oda

I just want to give you some feedback after our UGP Coaching sessions. They were excellent and I would recommend you, and have recommended you, to business owners. I used a lot of your tips and one main one which grew one part of my business 15% over 8 weeks... and it is still growing - that was the re-activation letter in combination with a special invitation to join our Inner Sanctum. The Inner Sanctum is like a Platinum group of clients who enjoy special offers, new launch invites etc. Pretty much as for other types of business but not so common in Cosmetic Medicine. Your coaching really revitalised my enthusiasm for my business which extended to an increase in my team’s enthusiasm. Again, many thanks John.”

-Deirdre Tozer MD, Cosmetic Surgery Specialist, Australia